A Novel Paradigm for Cancer
To date, the classification of cancers has been based solely on the phenotypic and genotypic characteristics of tumor cells.
A new paradigm, scientifically well established and cited in WHO* classification of Tumours Series 5th edition, relies on the assessment of the immune response as a new risk feature related to clinical outcomes of colon cancer patients.
Maximize patient survival rates with an assessment of the tumor immune response.
*The World Health Organization is not endorsing the Immunoscore® commercial assay.
Immunoscore®
Immunity assessed, Personalized treatment
Immunoscore® is a test, recently included within ESMO guidelines, that predicts the risk of relapse in patients with localized colon cancer thereby facilitating the chemotherapy decision-making process.
Validated in a large international study conducted on more than 2500 Stage I-III colon cancer patients (Pagès et al, The Lancet 2018), Immunoscore® was demonstrated to be a powerful and independent prognostic factor for patient survival, providing the greatest contribution to patient prognostication of all assessed factors.
Discover how Immunoscore® is helping to predict the risk of Localized Colon Cancer recurrence in our short video.
How can Immunoscore® help patient management?
With localized colon cancer
Introducing Immunoscore® into routine clinical practice at diagnosis gives oncologists access to precision medicine for improving cancer management outcomes and can help to facilitate:
- Refinement of patient risk profiles by providing a greater prognostic value compared to traditional measurements.
- Adjustment of treatment decisions and improved colon cancer patient management.
- Optimization of adjuvant chemotherapy duration.
- Personalization of patient follow-up.
Clinical Data and Clinical Utility
Role of Immunoscore in Colon and Rectal Cancer
Presentation by Prof. Claus-Henning Köhne at IGICC Congress
Watch testimonials from gastrointestinal oncologists around the world on how Immunoscore® is improving their daily practice here
How does Immunoscore® work?
The Immunoscore® is a tissue-based immune assay performed on formalin-fixed paraffin-embedded (FFPE) tumor tissue samples of primary colon cancer intended to measure the host immune response at the tumor site.
In combination with standard clinicopathologic features, this digital diagnostic test informs adjuvant chemotherapy decision-making for patients with early-stage colon cancer.
Immunoscore® values are reported based on pre-defined cut-offs in 5 categorical scores (IS 0 to 4) and in 2 categories of recurrence risk: Immunoscore® Low (IS 0 &1) and Immunoscore® High (IS 2 to 4), with a higher Immunoscore® associated with a lower risk of recurrence (Pagès F et al. The Lancet 2018, Sinicrope F et al. JNCI Cancer Spectrum 2020, Pages et al. Ann Oncol. 2020).
In validation studies of stage III colon cancers, only Immunoscore® High patients experienced a significant therapy benefit (Pages et al. Ann Oncol. 2020, Mlecnik et al. J Clin Oncol.2020).
A personalized Immunoscore® in two categories is provided and sent 10 working days after receipt of specimen for an informed and shared therapeutic decision-making.
The test is CE-IVD marked for Europe and performed as a CLIA service in our laboratories in Marseille, France and Richmond, Virginia.
How to Order
Your contact:
HalioDx
Oncologists and patients are invited to contact HalioDx which markets and distributes Immunoscore® assay in your country.
Luminy Biotech Entreprises
163 Avenue de Luminy
13288 Marseille Cedex 9
FRANCE
Phone: +33 (0) 4 91 29 30 90
Find out more about Immunoscore® contact us
Resources
#brochure | Sep. 2021
Brochure Immunoscore® in Localized CC (CE/IVD version)
For Healthcare Professionals (CE/IVD version)
#brochure | Sep. 2021
Leaflet Immunoscore® in Stage III Colon Cancer
For Healthcare Professionals (English version)
#brochure | Sep. 2021
Leaflet Immunoscore® in Stage II Colon Cancer
For Healthcare Professionals (English version)
#brochure | Sep. 2021
Leaflet Immunoscore® in High-risk Stage II Colon Cancer
For Healthcare Professionals (English version)
#brochure | Sep. 2021
Brochure Immunoscore® in Localized CC (CLIA US version)
For Healthcare Professionals (CLIA US version)
#brochure | Sep. 2021
Brochure Immunoscore® in Localized Colon Cancer
For Patients & Caregivers (English)
#video | Jan. 2021
Dr Mellor, Malaysia, explains why and how he is using immmunoscore in Stage III colon cancer patients
#video | Dec. 2020
Professor Yoshino, KOL in Asia region, talk about Immunoscore
#poster | Nov. 2020
ASCO Quality Care Symposium on October 9-10, 2020
Impact of Immune Assessment with Immunoscore® on Patterns of Care In Stage II Colon Cancer
#video | Oct. 2020
Dr Tony Dhillon (UK) presenting Immunoscore at the Digestive Cancers Europe Scientific Update: Role of the Immune Response in Early Stage Colorectal Cancers
#video | Oct. 2020
Testimonial: Dr Su Pin Choo (Curie Oncology, Singapore) on the utility of Immunoscore in early stage Colon Cancer
#video | Oct. 2020
Managing colorectal cancer patients in the COVID-19 era with Drs Benjamin Weinberg (USA), Matías Chacón and Juan Manuel O’Connor (both Argentina)
#publication | Sep. 2020
Mlecnik B Bifulco C, Bindea G, et al.
Multicenter International Society for Immunotherapy of Cancer Study of the Consensus Immunoscore for the Prediction of Survival and Response to Chemotherapy in Stage III Colon Cancer
J Clin Oncol.
#publication | Aug. 2020
El Sissy C, Kirilovsky A, Van den Eynde M et al.
A Diagnostic Biopsy-Adapted Immunoscore Predicts Response to Neoadjuvant Treatment and Selects Patients with Rectal Cancer Eligible for a Watch-and-Wait Strategy
Clin Cancer Res
#publication | Aug. 2020
F Pages, J Taieb, P Laurent-Puig, and J Galon
The consensus Immunoscore in phase 3 clinical trials; potential impact on patient management decisions
OncoImmunology
#publication | Aug. 2020
Bruni D, K Angell H and Galon J
The immune contexture and Immunoscore in cancer prognosis and therapeutic efficacy
Nature Reviews Cancer
#video | Jul. 2020
Immunoscore® highlights at ESMO GI. Presentations of Dr Le Bagousse and Jérôme Galon, PhD
#publication | Jul. 2020
A Lanzi,F.A Sinicrope, A.B Benson, and J Galon
The consensus Immunoscore in phase 3 clinical trial (N0147) and impact on patient management decisions
OncoImmunology
#publication | Jun. 2020
A Lanzi,F Pages, C Lagorce-Pages, and J Galon
The consensus immunoscore: toward a new classification of colorectal cancer
OncoImmunology
#publication | Jun. 2020
O’Connor JM, Esteso F & Chacón M
Official French SARS-CoV-2 guidelines for cancer patients, a triage solution with precision medicine
Future Medicine
#video | Jun. 2020
Testimonial: Dr Juan Manuel O’Connor (Instituto Alexander Fleming in Buenos Aires, Argentina) on the use of Immunoscore in routine practice in managing early Colon Cancer
#e-news | Jun. 2020
Factsheet Immunoscore® & COVID-19 Colon Cancer Guidelines
#poster | May. 2020
Poster presented at ASCO20 Virtual Scientific meeting#ASCO20
Immunoscore is the most powerful parameter predicting time to recurrence and disease-free survival in T4N0 stage II colon cancer patients Abstract 4105
#publication | May. 2020
Marliot F, Chen X, Kirilovsky A et al.
Analytical validation of the Immunoscore and its associated prognostic value in patients with colon cancer
BMJ
#e-news | May. 2020
Expert Opinion: The Role of Microbiota and its Impact on the Tumor Microenvironment in Colorectal Cancer | Dr Benjamin A. Weinberg, MD, Oncologist in Georgetown, Washington DC
#e-news | Apr. 2020
Expert Opinion: Immunity and cancer | Dr Angela Alistar, MD, Oncologist in Morristown, NJ
#publication | Apr. 2020
Pages F, Andre T, Taieb J et al.
Prognostic and Predictive Value of the Immunoscore in Stage III Colon Cancer Patients Treated With Oxaliplatin in the Prospective IDEA France PRODIGE-GERCOR Cohort Study
Annals of Oncology
#publication | Apr. 2020
Sinicrope F, Shi Q, Hermitte F et al.
Contribution of Immunoscore and Molecular Features to Survival Prediction in Stage III Colon Cancer
JNCI Cancer Spectrum
#publication | Mar. 2020
Blair H
Immunoscore®: A Diagnostic Assay for Clinical Management of Colon Cancer
Molecular Diagnosis & Therapy volume
#video | Mar. 2020
Franck Pagès, MD, PhD, on Selecting Patients With Advanced Colon Cancer for Treatment
#poster | Jan. 2020
Poster presented at Gastro Intestinal Symposium #GI20
Prognostic and predictive value of the Immunoscore in stage III colon cancer patients treated with mFOLFOX6 (3 vs 6 months) in the prospective IDEA France cohort study
#publication | Jan. 2020
Pagès F, Kirilovsky A, Mlecnik B et al.
In situ cytotoxic and memory T cells predict outcome in patients with early-stage colorectal cancer.
Journal of Clinical Oncology
#brochure | Sep. 2021
Brochure Immunoscore® in Localized Colon Cancer - SPANISH
For Patients & Caregivers (Spanish)
#video | Sep. 2019
Webinar Immunoscore®: IDEA France study results in Stage III Colon Cancer - Sept. 19, 2019 | Franck Pagès, Eric Van Cutsem
#publication | Aug. 2019
Angell HK, Bruni D, Barrett JC et al.
The Immunoscore: Colon Cancer and Beyond.
Clin Cancer Res.
#poster | Jul. 2019
Poster presented at ESMO GI 2019
Significant differences in outcome between Immunoscore categories in stage I colon cancer patients
#video | Jun. 2019
Extract of an interview by Cancer.fr of Professor Thierry André, on Immunoscore® in the IDEA France study (in French)
#video | Jun. 2019
Jérôme Galon, winner for the European Inventor Award 2019 for Immunoscore®
#poster | Jun. 2019
Poster presented at ASCO 2019
Validation of the Immunoscore Prognostic Value in Stage III Colon Cancer Patients treated with Oxaliplatin in the prospective IDEA France cohort study (PRODIGE-GERCOR).
#publication | May. 2019
Pages F, Andre T, Taieb J et al.
Validation of the Immunoscore prognostic value in stage III colon cancer patients treated with oxaliplatin in the prospective IDEA France cohort study (PRODIGE-GERCOR)
Journal of Clinical Oncology
#video | Apr. 2019
Dr. Fakih Discusses the Utility of Immunoscore® in CRC
#video | Mar. 2019
Immunoscore® Webinar New data in Stage II Colon Cancer - March 21, 2019 | Jêrome Galon, PhD
#publication | Mar. 2019
Zeitoun G, Sissy CE, Kirilovsky A et al.
The Immunoscore in the Clinical Practice of Patients with Colon and Rectal Cancers.
Chirurgia (Bucur).
#video | Jan. 2019
Discover how Immunoscore® is predicting the risk of relapse in localized colon cancer in a short video
#poster | Jan. 2019
Poster presented at Gastrointestinal Cancers Symposium 2019
Immunoscore clinical utility to identify good prognostic Colon Cancer Stage II patients with high-risk clinico-pathological features for whom adjuvant treatment may be avoided
#poster | Dec. 2018
Poster presented at ESMO ASIA 2018
UCGI 34 - PROSCORE: A prospective study assessing whether Immunoscore® test impacts the choice of adjuvant chemotherapy, in a multidisciplinary meeting, for treating non-metastatic colon cancer patients after curative-intent surgery
#poster | Dec. 2018
Poster presented at ESMO IO 2018
MSI status plus Immunoscore to select metastatic colorectal cancer patients for immunotherapies
#poster | Nov. 2018
Poster presented at ESMO ASIA 2018
Immunoscore feasibility study in routine postsurgical pathologic review for early‐stage colon cancer (CC) cases risk‐assessment
#publication | Oct. 2018
Angelova M, Mlecnik B, Vasaturo A et al.
Evolution of Metastases in Space and Time under Immune Selection.
Cell
#video | Aug. 2018
Webinar on “Clinical utility of Immunoscore® in colon cancer” with Marc Van Den Eynde, MD, PhD | October 17, 2017
#video | Aug. 2018
Dr Jerome Galon on the Prognostic Value of Immunoscore, Onclive - ASCO 2016
#video | Aug. 2018
Immunoscore® Colon Symposium - June 1, 2018, Chicago | Discussion on clinical cases
#video | Aug. 2018
Immunoscore® Colon Symposium - June 1, 2018, Chicago | Jérôme Galon, PhD
#video | Aug. 2018
Immunoscore® Colon Symposium - June 1, 2018, Chicago | Stanley Hamilton, MD
#publication | May. 2018
Pagès F, Mlecnik B, Marliot F et al.
International validation of the consensus Immunoscore for the classification of colon cancer: a prognostic and accuracy study.
Lancet
#poster | Feb. 2018
Poster presented at ASCO GI 2018
Immunoscore provides prognostic information in low (T3N1) and high (T4 or N2) risk subsets of stage III colon carcinoma patients treated with adjuvant FOLFOX in a phase III trial [NCCTG N0147 (Alliance)
#publication | Feb. 2018
Sinicrope F, Shi Q, Hermitte F et al.
Immunoscore to provide prognostic information in low- (T1-3N1) and high-risk (T4 or N2) subsets of stage III colon carcinoma patients treated with adjuvant FOLFOX in a phase III trial (NCCTG N0147; Alliance).
J Clin Oncol.
#publication | Jan. 2018
Mlecnik B, Van den Eynde M, Bindea G et al.
Comprehensive Intrametastatic Immune Quantification and Major Impact of Immunoscore on Survival.
J Natl Cancer Inst.
#poster | Jun. 2017
Poster presented at ASCO 2017
Prognostic utility of immune markers and validation of Immunoscore® in stage III colon carcinoma patients treated with adjuvant FOLFOX in a phase III trial [NCCTG N0147 (Alliance)]
#publication | May. 2017
Sinicrope F, Shi Q, Hermitte F et al.
Association of immune markers and Immunoscore with survival of stage III colon carcinoma (CC) patients (pts) treated with adjuvant FOLFOX: NCCTG N0147 (Alliance).
J Clin Oncol.
#publication | May. 2017
Galon J, Mlecnik B, Marliot F et al.
Validation of the Immunoscore (IM) as a prognostic marker in stage I/II/III colon cancer: Results of a worldwide consortium-based analysis of 1,336 patients.
J Clin Oncol.
#poster | Nov. 2016
Poster presented at SITC 2016
Immunoscore® analytical performance
#publication | Sep. 2016
Hermitte F
Biomarkers immune monitoring technology primer: Immunoscore® Colon.
Journal for ImmunoTherapy of Cancer
#publication | Aug. 2016
Kirilovsky A, Marliot F, El Sissy C et al.
Rational bases for the use of the Immunoscore in routine clinical settings as a prognostic and predictive biomarker in cancer patients.
Int Immunol.
#publication | Mar. 2016
Mlecnik B, Bindea G, Angell HK et al.
Integrative Analyses of Colorectal Cancer Show Immunoscore Is a Stronger Predictor of Patient Survival Than Microsatellite Instability.
Immunity
#publication | Feb. 2016
Mlecnik B, Bindea G, Kirilovsky A et al.
The tumor microenvironment and Immunoscore are critical determinants of dissemination to distant metastasis.
Sci Transl Med.
#publication | Feb. 2011
Mlecnik B, Tosolini M, Kirilovsky A et al.
Histopathologic-based prognostic factors of colorectal cancers are associated with the state of the local immune reaction.
Journal of Clinical Oncology
#publication | Sep. 2006
Galon J, Costes A, Sanchez-Cabo F et al.
Type, density, and location of immune cells within human colorectal tumors predict clinical outcome.
Science